{"id":3126,"date":"2020-09-23T12:57:40","date_gmt":"2020-09-23T12:57:40","guid":{"rendered":"https:\/\/andrologylab.gr\/?page_id=3126"},"modified":"2026-03-20T20:04:37","modified_gmt":"2026-03-20T20:04:37","slug":"cystic-fibrosis","status":"publish","type":"page","link":"https:\/\/andrologylab.gr\/en\/services\/genetic-testing\/cystic-fibrosis\/","title":{"rendered":"Cystic fibrosis"},"content":{"rendered":"<style>.kb-row-layout-id3126_d381f2-18 > .kt-row-column-wrap{align-content:start;}:where(.kb-row-layout-id3126_d381f2-18 > .kt-row-column-wrap) > .wp-block-kadence-column{justify-content:start;}.kb-row-layout-id3126_d381f2-18 > .kt-row-column-wrap{column-gap:var(--global-kb-gap-md, 2rem);row-gap:var(--global-kb-gap-md, 2rem);max-width:var( --global-content-width, 1290px );padding-left:var(--global-content-edge-padding);padding-right:var(--global-content-edge-padding);padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px;grid-template-columns:minmax(0, 1fr);}.kb-row-layout-id3126_d381f2-18 > .kt-row-layout-overlay{opacity:0.30;}@media all and (max-width: 1024px){.kb-row-layout-id3126_d381f2-18 > .kt-row-column-wrap{grid-template-columns:minmax(0, 1fr);}}@media all and (max-width: 767px){.kb-row-layout-id3126_d381f2-18 > .kt-row-column-wrap{grid-template-columns:minmax(0, 1fr);}}<\/style><div class=\"kb-row-layout-wrap kb-row-layout-id3126_d381f2-18 alignwide wp-block-kadence-rowlayout\"><div class=\"kt-row-column-wrap kt-has-1-columns kt-row-layout-equal kt-tab-layout-inherit kt-mobile-layout-row kt-row-valign-top kb-theme-content-width\">\n<style>.kadence-column3126_118fc7-1a > .kt-inside-inner-col,.kadence-column3126_118fc7-1a > .kt-inside-inner-col:before{border-top-left-radius:0px;border-top-right-radius:0px;border-bottom-right-radius:0px;border-bottom-left-radius:0px;}.kadence-column3126_118fc7-1a > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column3126_118fc7-1a > .kt-inside-inner-col{flex-direction:column;}.kadence-column3126_118fc7-1a > .kt-inside-inner-col > .aligncenter{width:100%;}.kadence-column3126_118fc7-1a > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column3126_118fc7-1a{position:relative;}@media all and (max-width: 1024px){.kadence-column3126_118fc7-1a > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}@media all and (max-width: 767px){.kadence-column3126_118fc7-1a > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}<\/style>\n<div class=\"wp-block-kadence-column kadence-column3126_118fc7-1a\"><div class=\"kt-inside-inner-col\">\n<h2 class=\"wp-block-heading\">What is cystic fibrosis?<\/h2>\n\n\n\n<p>Cystic fibrosis is the second most common genetic disease in Europe. Sufferers experience significantly shorter life expectancy and high morbidity due to the production of viscous secretions in the respiratory and gastrointestinal systems, which lead to gradual destruction of organs in these systems (lungs, pancreas, etc.).<br>In cystic fibrosis, due to gene mutations, a change is made in a protein called the cystic fibrosis transmembrane conduction regulator (CFTR). This protein is responsible for transporting chloride from inside to outside of the membrane.<br>Testing for cystic fibrosis mutations is mandatory &nbsp;in infertile couples. Of primary interest is of course the health of the fetus: if the parents are both carriers of a cystic fibrosis mutation then the fetus will suffer from cystic fibrosis, which is a very serious disease. If a mutation is found in one parent, it is necessary for the other parent to do the test to prevent the transmission of the disease to the fetus.<br>Men diagnosed with azoospermia are always tested for mutations of the cystic fibrosis gene: if a mutation exists one or both spermatic cords may be absent and this is the cause of azzospermia.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How is cystic fibrosy tested?<\/h2>\n\n\n\n<p>More than 2000 mutations in the CFTR gene have been identified, with the \u0394f508 mutation being the most common one. The mutation \u0394f508 covers only 50% of cases of this serious disease, so it is advised to test the entire gene for mutations using the next-generation sequencing (NGS).<\/p>\n<\/div><\/div>\n\n<\/div><\/div>\n\n<style>.kb-row-layout-id3126_fbbd07-86 > .kt-row-column-wrap{align-content:start;}:where(.kb-row-layout-id3126_fbbd07-86 > .kt-row-column-wrap) > .wp-block-kadence-column{justify-content:start;}.kb-row-layout-id3126_fbbd07-86 > .kt-row-column-wrap{column-gap:var(--global-kb-gap-md, 2rem);row-gap:var(--global-kb-gap-md, 2rem);max-width:var( --global-content-width, 1290px );padding-left:var(--global-content-edge-padding);padding-right:var(--global-content-edge-padding);padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px;grid-template-columns:minmax(0, 1fr);}.kb-row-layout-id3126_fbbd07-86 > .kt-row-layout-overlay{opacity:0.30;}@media all and (max-width: 1024px){.kb-row-layout-id3126_fbbd07-86 > .kt-row-column-wrap{grid-template-columns:minmax(0, 1fr);}}@media all and (max-width: 767px){.kb-row-layout-id3126_fbbd07-86 > .kt-row-column-wrap{grid-template-columns:minmax(0, 1fr);}}<\/style><div class=\"kb-row-layout-wrap kb-row-layout-id3126_fbbd07-86 alignwide wp-block-kadence-rowlayout\"><div class=\"kt-row-column-wrap kt-has-1-columns kt-row-layout-equal kt-tab-layout-inherit kt-mobile-layout-row kt-row-valign-top kb-theme-content-width\">\n<style>.kadence-column3126_d75086-80 > .kt-inside-inner-col,.kadence-column3126_d75086-80 > .kt-inside-inner-col:before{border-top-left-radius:0px;border-top-right-radius:0px;border-bottom-right-radius:0px;border-bottom-left-radius:0px;}.kadence-column3126_d75086-80 > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column3126_d75086-80 > .kt-inside-inner-col{flex-direction:column;}.kadence-column3126_d75086-80 > .kt-inside-inner-col > .aligncenter{width:100%;}.kadence-column3126_d75086-80 > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column3126_d75086-80{position:relative;}@media all and (max-width: 1024px){.kadence-column3126_d75086-80 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}@media all and (max-width: 767px){.kadence-column3126_d75086-80 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}<\/style>\n<div class=\"wp-block-kadence-column kadence-column3126_d75086-80\"><div class=\"kt-inside-inner-col\"><div class=\"alab-child-pages alab-grid-4\"><a class=\"alab-child-card card-L1\" href=\"https:\/\/andrologylab.gr\/en\/services\/genetic-testing\/y-chromosome-microdeletions-azf\/\"><div class=\"alab-child-image\"><img loading=\"lazy\" decoding=\"async\" width=\"1\" height=\"1\" src=\"https:\/\/andrologylab.gr\/wp-content\/uploads\/2021\/04\/mikroelleipseis-tou-chromosomatos-Y-AZF.jpg\" class=\"alab-child-thumb wp-post-image\" alt=\"\u0391\u03bd\u03b4\u03c1\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03cc \u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03ae\u03c1\u03b9\u03bf \u0396\u03b5\u03b3\u03ba\u03b9\u03bd\u03b9\u03ac\u03b4\u03bf\u03c5 \u039c\u03b9\u03ba\u03c1\u03bf\u03b2\u03b9\u03bf\u03bb\u03bf\u03b3\u03af\u03b1 \u03c7\u03c1\u03c9\u03bc\u03cc\u03c3\u03c9\u03bc\u03b1 \u03a5\" \/><\/div><div class=\"alab-child-text\"><h3 class=\"alab-child-title\">Y chromosome microdeletions (AZF)<\/h3><p class=\"alab-child-excerpt\">The integrity of the Y chromosome is important for the production of spermatozoa. In some cases small parts of the&hellip;<\/p><span class=\"alab-child-more\">more<\/span><\/div><\/a><a class=\"alab-child-card card-L2\" href=\"https:\/\/andrologylab.gr\/en\/services\/genetic-testing\/fish-on-sperm\/\"><div class=\"alab-child-image\"><img loading=\"lazy\" decoding=\"async\" width=\"1\" height=\"1\" src=\"https:\/\/andrologylab.gr\/wp-content\/uploads\/2021\/01\/FISH-sta-spermatozoaria.jpg\" class=\"alab-child-thumb wp-post-image\" alt=\"FISH \u03c3\u03c4\u03b1 \u03c3\u03c0\u03b5\u03c1\u03bc\u03b1\u03c4\u03bf\u03b6\u03c9\u03ac\u03c1\u03b9\u03b1\" \/><\/div><div class=\"alab-child-text\"><h3 class=\"alab-child-title\">FISH on sperm<\/h3><p class=\"alab-child-excerpt\">What is FISH on sperm? One of the most important techniques developed in recent years is \u201c FISH\u201d, from the&hellip;<\/p><span class=\"alab-child-more\">more<\/span><\/div><\/a><a class=\"alab-child-card card-L3\" href=\"https:\/\/andrologylab.gr\/en\/services\/genetic-testing\/karyotype\/\"><div class=\"alab-child-image\"><img loading=\"lazy\" decoding=\"async\" width=\"1\" height=\"1\" src=\"https:\/\/andrologylab.gr\/wp-content\/uploads\/2021\/04\/karyotypos.jpg\" class=\"alab-child-thumb wp-post-image\" alt=\"\u0391\u03bd\u03b4\u03c1\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03cc \u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03ae\u03c1\u03b9\u03bf \u0396\u03b5\u03b3\u03ba\u03b9\u03bd\u03b9\u03ac\u03b4\u03bf\u03c5 \u03ba\u03b1\u03c1\u03c5\u03cc\u03c4\u03c5\u03c0\u03bf\u03c2\" \/><\/div><div class=\"alab-child-text\"><h3 class=\"alab-child-title\">Karyotype<\/h3><p class=\"alab-child-excerpt\">What does the karyotype show? In humans, each cell contains 23 pairs of chromosomes, of which 22 pairs are called&hellip;<\/p><span class=\"alab-child-more\">more<\/span><\/div><\/a><a class=\"alab-child-card card-L4\" href=\"https:\/\/andrologylab.gr\/en\/services\/genetic-testing\/general-information\/\"><div class=\"alab-child-image\"><img loading=\"lazy\" decoding=\"async\" width=\"1\" height=\"1\" src=\"https:\/\/andrologylab.gr\/wp-content\/uploads\/2021\/04\/genetikos-elegchos-genikes-plirofories.jpg\" class=\"alab-child-thumb wp-post-image\" alt=\"\u0391\u03bd\u03b4\u03c1\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03cc \u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03ae\u03c1\u03b9\u03bf \u0396\u03b5\u03b3\u03ba\u03b9\u03bd\u03b9\u03ac\u03b4\u03bf\u03c5 \u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03cc\u03c2 \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2\" \/><\/div><div class=\"alab-child-text\"><h3 class=\"alab-child-title\">General Information<\/h3><p class=\"alab-child-excerpt\">All human cells, spermatozoa included, contain genetic material that determines everything that a cell must do, that is, to feed,&hellip;<\/p><span class=\"alab-child-more\">more<\/span><\/div><\/a><\/div>\n<\/div><\/div>\n\n<\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>What is cystic fibrosis? Cystic fibrosis is the second most common genetic disease in Europe. Sufferers experience significantly shorter life expectancy and high morbidity due to the production of viscous secretions in the respiratory and gastrointestinal systems, which lead to gradual destruction of organs in these systems (lungs, pancreas, etc.).In cystic fibrosis, due to gene&#8230;<\/p>\n","protected":false},"author":5,"featured_media":4609,"parent":3104,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_kad_blocks_custom_css":"","_kad_blocks_head_custom_js":"","_kad_blocks_body_custom_js":"","_kad_blocks_footer_custom_js":"","_kadence_starter_templates_imported_post":false,"_kad_post_transparent":"","_kad_post_title":"","_kad_post_layout":"","_kad_post_sidebar_id":"","_kad_post_content_style":"","_kad_post_vertical_padding":"","_kad_post_feature":"","_kad_post_feature_position":"","_kad_post_header":false,"_kad_post_footer":false,"_kad_post_classname":"","footnotes":""},"class_list":["post-3126","page","type-page","status-publish","has-post-thumbnail","hentry"],"taxonomy_info":[],"featured_image_src_large":["https:\/\/andrologylab.gr\/wp-content\/uploads\/2021\/01\/kystiki-inosi.jpg",150,150,false],"author_info":{"display_name":"andrologyadmin","author_link":"https:\/\/andrologylab.gr\/en\/author\/andrologyadmin\/"},"comment_info":0,"_links":{"self":[{"href":"https:\/\/andrologylab.gr\/en\/wp-json\/wp\/v2\/pages\/3126","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/andrologylab.gr\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/andrologylab.gr\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/andrologylab.gr\/en\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/andrologylab.gr\/en\/wp-json\/wp\/v2\/comments?post=3126"}],"version-history":[{"count":1,"href":"https:\/\/andrologylab.gr\/en\/wp-json\/wp\/v2\/pages\/3126\/revisions"}],"predecessor-version":[{"id":5564,"href":"https:\/\/andrologylab.gr\/en\/wp-json\/wp\/v2\/pages\/3126\/revisions\/5564"}],"up":[{"embeddable":true,"href":"https:\/\/andrologylab.gr\/en\/wp-json\/wp\/v2\/pages\/3104"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/andrologylab.gr\/en\/wp-json\/wp\/v2\/media\/4609"}],"wp:attachment":[{"href":"https:\/\/andrologylab.gr\/en\/wp-json\/wp\/v2\/media?parent=3126"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}